2018年8月31日星期五

Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin

Manipulating Aggregation Behavior of the Uncharged Peptide Carbetocin

UB Høgstedt, J Østergaard, T Weiss, H Sjögren… - Journal of …, 2018 - Elsevier
Peptides are usually administered through subcutaneous injection. For low potency drugs,
this may require high concentration formulations increasing the risk of peptide aggregation,
especially for compounds without any intrinsic chargeable groups. Carbetocin was used as …

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