2018年8月30日星期四

Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy

Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy

F Niu, J Yan, B Ma, S Li, Y Shao, P He, W Zhang, W He… - Biomaterials, 2018 - Elsevier
Roughly one third of all human cancers are attributable to the functional inhibition of the
tumor suppressor protein p53 by its two negative regulators MDM2 and MDMX, making dual-
specificity peptide antagonists of MDM2 and MDMX highly attractive drug candidates for …


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