GFR alpha 3 Antibody

Product	GFR alpha 3 Antibody
Cat#	100-8-03A
Unit/Weight	100 μg
Unit Price	$311.00
Species Reactivity	H, M, R
Tested Application(s)	E, WB, IHC
Brief Description	(IN) Persephin receptor a new member of the GDNF family was recently identified and designated persephin.
Specific Description	Members of the glial cell line-derived neurotrophic factor (GDNF) family including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRalpha and Ret receptor tyrosine kinase GFRbeta (2). Following the findings of GFRΑ-1 and -2, a novel receptor in GFRalpha family was identified very recently from human and mouse and designated GFRalpha-3. GFRalpha-3 binds persephin, thus, persephin, GFRalpha-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
Storage	GFR alpha 3 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.