2019年2月18日星期一

Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor

Hit evaluation of an α-helical peptide: Ala-scan, truncation and sidechain-to-sidechain macrocyclization of an RNA polymerase Inhibitor

AAM Kamal, M Habib, J Haupenthal… - Biological …, 2019 - degruyter.com
RNA polymerase (RNAP) remains a relatively underexplored target with only rifampicin and
fidaxomicin in clinical use. Hence, the concurrent rise in bacterial resistance rate urges the
search for novel RNAP inhibitors with a novel mode of action. In this work, we investigated …


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