[HTML] Characterization and quantification of succinimide using peptide mapping under low-pH conditions and hydrophobic interaction chromatography

[HTML] Characterization and quantification of succinimide using peptide mapping under low-pH conditions and hydrophobic interaction chromatography

M Cao, SHR Mulagapati, B Vemulapalli, J Wang… - Analytical …, 2019 - Elsevier

Abstract Characterization of asparagine deamidation and aspartic acid isomerization is an
important aspect of biotherapeutic protein analysis due to the potential negative effect of
these modifications on drug efficacy and stability. Succinimide has long been known to be …

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