Discovery of peptide ligands targeting a specific ubiquitin-like domain–binding site in the deubiquitinase USP11

Discovery of peptide ligands targeting a specific ubiquitin-like domain–binding site in the deubiquitinase USP11

A Spiliotopoulos, LB Ferreras, RM Densham… - Journal of Biological …, 2019 - ASBMB

Ubiquitin-specific proteases (USPs) reverse ubiquitination and regulate virtually all cellular
processes. Defined noncatalytic domains in USP4 and USP15 are known to interact with E3
ligases and substrate recruitment factors. No such interactions have been reported for these …

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