2019年3月31日星期日

Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance

Ribosomal Proteins Regulate MHC Class I Peptide Generation for Immunosurveillance

J WeiRJ Kishton, M Angel, CS Conn, N Dalla-Venezia… - Molecular cell, 2019 - Elsevier
The MHC class I antigen presentation system enables T cell immunosurveillance of cancers
and viruses. A substantial fraction of the immunopeptidome derives from rapidly degraded
nascent polypeptides (DRiPs). By knocking down each of the 80 ribosomal proteins, we …


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