Aeromonas hydrophila PepO outer membrane endopeptidase activates human big endothelin-3 in vitro and induces skin ulcer in goldfish (Carassius auratus)

Aeromonas hydrophila PepO outer membrane endopeptidase activates human big endothelin-3 in vitro and induces skin ulcer in goldfish (Carassius auratus)

SK Abolghait, Y Akeda, T Kodama, VV Cantarelli… - Veterinary …, 2010 - Elsevier

... To determine the in vitro PepO enzymatic substrate specificity, 1 μM of each of the big endothelins
(ET-1, ET-2 or ET-3, purchased from the Peptide Institute Inc., Osaka, Japan) was incubated with
equal amounts of A. hydrophila bacterial pellets or purified rGST-PepO ...

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