Improving the Binding Affinity of in‐Vitro‐Evolved Cyclic Peptides by Inserting Atoms into the Macrocycle Backbone

Improving the Binding Affinity of in‐Vitro‐Evolved Cyclic Peptides by Inserting Atoms into the Macrocycle Backbone

J Wilbs, SJ Middendorp, C Heinis - ChemBioChem, 2016 - Wiley Online Library

... Peptides were prepared as 2 mm stock solutions in H 2 O. Residual enzymatic activity ... FXIIa
(#HFXIIAB; Molecular Innovations, Novi, MI) was 0.5 or 1 nm, with peptide at 10 ... nm. The final
concentration of the fluorogenic substrate Boc-QGR-AMC (Bachem, Bubendorf, Switzerland ...

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