Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration
R Perlikowska, J Piekielna, L Gentilucci… - European journal of …, 2016 - Elsevier
... reduce the molecular conformational freedom, stabilize the peptide in biological fluids and
increase membrane permeation, the cyclization of linear sequences was frequently adopted
in peptide chemistry [11], [12], [13] and [14]. The structure of cyclic peptides could be ...
increase membrane permeation, the cyclization of linear sequences was frequently adopted
in peptide chemistry [11], [12], [13] and [14]. The structure of cyclic peptides could be ...

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