[HTML] Creation of apolipoprotein C-II (ApoC-II) mutant mice and correction of their hypertriglyceridemia with an ApoC-II mimetic peptide

[HTML] Creation of apolipoprotein C-II (ApoC-II) mutant mice and correction of their hypertriglyceridemia with an ApoC-II mimetic peptide

T Sakurai, A Sakurai, BL Vaisman, MJ Amar… - … of Pharmacology and …, 2016 - ASPET

Apolipoprotein C-II (apoC-II) is a cofactor for lipoprotein lipase, a plasma enzyme that
hydrolyzes triglycerides (TGs). ApoC-II deficiency in humans results in hypertriglyceridemia.
We used zinc finger nucleases to create Apoc2 mutant mice to investigate the use of C-II-a, a …

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