Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages

Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages

F De Falco, C Di Giovanni, C Cerchia… - Biochemical …, 2016 - Elsevier

Abstract Nuclear Factor-κB (NF-κB) is a transcription factor regulating several genes
involved in important physiological and pathological processes. NF-κB has been found
constitutively activated in many inflammatory/immune diseases. In addition, a positive …

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