Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design
O Van der Poorten, A Knuhtsen… - Journal of medicinal …, 2016 - ACS Publications
Constraining the conformation of flexible peptides is a proven strategy to increase potency,
selectivity, and metabolic stability. The focus has mostly been on constraining the backbone
dihedral angles; however, the correct orientation of the amino acid side chains (χ-space) that …
selectivity, and metabolic stability. The focus has mostly been on constraining the backbone
dihedral angles; however, the correct orientation of the amino acid side chains (χ-space) that …
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