2018年9月2日星期日

A Tumor Targeted Chimeric Peptide for Synergistic Endosomal Escape and Therapy by Dual‐Stage Light Manipulation

A Tumor Targeted Chimeric Peptide for Synergistic Endosomal Escape and Therapy by Dual‐Stage Light Manipulation

K Han, Q Lei, HZ Jia, SB Wang, WN Yin… - Advanced Functional …, 2015 - Wiley Online Library
In this study, a pH sensitive chimeric peptide is developed to codeliver a photosensitizer,
protoporphyrin IX (PpIX), and plasmid DNA simultaneously. In the presence of matrix
metalloproteinase‐2 (MMP‐2), the chimeric peptide undergoes the process of hydrolysis of …


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