Structure-guided design of a cell penetrating peptide preventing cAMP modulation of HCN channels
The auxiliary subunit TRIP8b prevents cAMP activation of HCN channels by antagonizing its
binding to their cyclic-nucleotide binding domain (CNBD). By determining an NMR-derived
structure of the complex formed by the HCN2 channel CNBD and a minimal TRIP8b …
binding to their cyclic-nucleotide binding domain (CNBD). By determining an NMR-derived
structure of the complex formed by the HCN2 channel CNBD and a minimal TRIP8b …
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