Design and synthesis of non-peptide, selective orexin receptor 2 agonists
T Nagahara, T Saitoh, N Kutsumura… - Journal of medicinal …, 2015 - ACS Publications
Orexins are a family of neuropeptides that regulate sleep/wakefulness, acting on two G-
protein-coupled receptors, orexin receptors 1 (OX1R) and 2 (OX2R). Genetic and
pharmacologic evidence suggests that orexin receptor agonists, especially OX2R agonist …
protein-coupled receptors, orexin receptors 1 (OX1R) and 2 (OX2R). Genetic and
pharmacologic evidence suggests that orexin receptor agonists, especially OX2R agonist …
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