Peptide/Protein Stapling and Unstapling: Introduction of s-Tetrazine, Photochemical Release, and Regeneration of the Peptide/Protein

Peptide/Protein Stapling and Unstapling: Introduction of s-Tetrazine, Photochemical Release, and Regeneration of the Peptide/Protein

SP Brown, AB Smith III - Journal of the American Chemical …, 2015 - ACS Publications

Protocols have been achieved that permit facile introduction of s-tetrazine into unprotected
peptides and the protein, thioredoxin, between two cysteine sulfhydryl groups (ie, staple),
followed by photochemical release (ie, unstaple) and regeneration of the peptide/protein …

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