2018年10月31日星期三

Addition of or switch to insulin therapy in people treated with glucagon‐like peptide‐1 receptor agonists: A real‐world study in 66 583 patients

Addition of or switch to insulin therapy in people treated with glucagon‐like peptide‐1 receptor agonists: A real‐world study in 66 583 patients

O Montvida, K Klein, S Kumar… - Diabetes, Obesity and …, 2017 - Wiley Online Library
Background Real world outcomes of addition or switch to insulin therapy in type 2 diabetes
(T2DM) patients on glucagon‐like paptide‐1 receptor agonist (GLP‐1RA) with inadequately
controlled hyperglycaemia, are not known. Materials and methods Patients with T2DM (n …



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The Role of Glucagon-Like Peptide-1 for the Postprandial Effects of Metformin in Type 2 Diabetes

The Role of Glucagon-Like Peptide-1 for the Postprandial Effects of Metformin in Type 2 Diabetes

LS HANSEN, LS GASBJERG, A BRØNDEN… - 2018 - Am Diabetes Assoc
Metformin is the most widely used plasma glucose-lowering drug for the treatment of type 2
diabetes. It has been shown that metformin increases plasma concentrations of glucagon-
like peptide-1 (GLP-1), but it remains unknown whether metformin-induced GLP-1 secretion …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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[HTML] Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

[HTML] Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

S Thellung, B Scoti, A Corsaro, V Villa, M Nizzari… - Cell death & …, 2018 - nature.com
According to the “gain-of-toxicity mechanism”, neuronal loss during cerebral proteinopathies
is caused by accumulation of aggregation-prone conformers of misfolded cellular proteins,
although it is still debated which aggregation state actually corresponds to the neurotoxic …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Antimicrobials inspired by nonribosomal peptide synthetase gene clusters

Antimicrobials inspired by nonribosomal peptide synthetase gene clusters

X Vila-Farres, J Chu, D Inoyama… - Journal of the …, 2017 - ACS Publications
Bacterial culture broth extracts have been the starting point for the development of numerous
therapeutics. However, only a small fraction of bacterial biosynthetic diversity is accessible
using this strategy. Here, we apply a discovery approach that bypasses the culturing step …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Solid-phase synthesis of peptide selenoesters via a side-chain anchoring strategy

Solid-phase synthesis of peptide selenoesters via a side-chain anchoring strategy

CC Hanna, SS Kulkarni, EE Watson… - Chemical …, 2017 - pubs.rsc.org
Peptide selenoesters have recently emerged as key building blocks for the ligation-based
assembly of large polypeptides and proteins. Herein, we report an efficient solid-phase
method for the high yielding and epimerisation-free synthesis of peptide selenoesters using …


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Prognostic role of molecular forms of B-type natriuretic peptide in acute heart failure

Prognostic role of molecular forms of B-type natriuretic peptide in acute heart failure

T Suzuki, MZ Israr, LM Heaney, M Takaoka… - Clinical …, 2017 - clinchem.aaccjnls.org
Background: B-type natriuretic peptide (BNP) molecular forms 5–32, 4–32, and 3–32 are
known to be present in the circulation of heart failure (HF) patients. This study investigated
the prognostic role of circulating BNP molecular forms on risk prediction for patients with …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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TIP47 Antibody

Product  TIP47 Antibody
Cat#  100-21-153A
Unit/Weight  100 μg
Unit Price  $311.00
Species Reactivity  H, R
Tested Application(s)  E, WB, IHC
Brief Description  (CT) golgi, intracellular traffic, rab9
Specific Description  Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.
Storage  TIP47 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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TIP47 Antibody

Product  TIP47 Antibody
Cat#  100-21-154A
Unit/Weight  100 μg
Unit Price  $311.00
Species Reactivity  H, M, R
Tested Application(s)  E, WB, IHC
Brief Description  (NT) golgi, intracellular traffic, rab9
Specific Description  Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.
Storage  TIP47 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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TLR3 Antibody

Product  TLR3 Antibody
Cat#  100-21-155A
Unit/Weight  100 μg
Unit Price  $311.00
Species Reactivity  H, M
Tested Application(s)  E, WB, ICC
Brief Description  (NT) Toll-like receptor
Specific Description  Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection (4). Recently it has been shown to recognize viruses such as Influenza A (5) and West Nile Virus and can mediate entry of at least West Nile Virus (6).
Storage  TLR3 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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TLR5 Antibody

Product  TLR5 Antibody
Cat#  100-21-156A
Unit/Weight  100 μg
Unit Price  $311.00
Species Reactivity  H, M, R
Tested Application(s)  E, WB, IHC
Brief Description  (IN) Toll-like receptor
Specific Description  Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-kappaB, leading to the activation of TNF-Α and other cytokines (4). A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response (5).
Storage  TLR5 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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TLR5 Antibody

Product  TLR5 Antibody
Cat#  100-21-157A
Unit/Weight  100 μg
Unit Price  $311.00
Species Reactivity  H, M
Tested Application(s)  E, WB, ICC
Brief Description  (CT) Toll-like receptor
Specific Description  Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR5 recognizes flagellin from both Gram-positive and Gram-negative bacteria and will cause the activation of NF-kappaB, leading to the activation of TNF-Α and other cytokines (4). A common TLR5 stop codon polymorphism that disrupts TLR5 signaling is associated with susceptibility to Legionnaires’ disease and demonstrates the importance of TLR5 in the innate immune response (5).
Storage  TLR5 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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TLR6 Antibody

Product  TLR6 Antibody
Cat#  100-21-159A
Unit/Weight  100 μg
Unit Price  $311.00
Species Reactivity  H
Tested Application(s)  E, WB, IHC
Brief Description  (IN) Toll-like receptor
Specific Description  Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify (4). Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan (5). Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses (6).
Storage  TLR6 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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2018年10月30日星期二

Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries

Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries

NYH Leung, CYY Wai, MHK Ho, R Liu… - Cellular & molecular …, 2017 - nature.com
The one-bead-one-compound (OBOC) combinatorial peptide library is a powerful tool to
identify ligand and receptor interactions. Here, we applied the OBOC library technology to
identify mimotopes specific to the immunoglobulin E (IgE) epitopes of the major shellfish …


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*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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[HTML] The small peptide world in long noncoding RNAs

[HTML] The small peptide world in long noncoding RNAs

SW Choi, HW Kim, JW Nam - Briefings in bioinformatics, 2018 - academic.oup.com
Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200
nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel
lncRNAs have been annotated in animal and plant genomes because of advanced high …


For custom peptides, please visit www.pepmic.com. Our peptide services including but not limited to:
*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Molecular topology of the transit peptide during chloroplast protein import

Molecular topology of the transit peptide during chloroplast protein import

LGL Richardson, EL Small, H Inoue, DJ Schnell - The Plant Cell, 2018 - Am Soc Plant Biol
Chloroplast protein import is directed by the interaction of the targeting signal (transit
peptide) of nucleus-encoded preproteins with translocons at the outer (TOC) and inner (TIC)
chloroplast envelope membranes. Studies of the energetics and determinants of transit …


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*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

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Pepmic Co., Ltd
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[HTML] A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

[HTML] A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

Y Yu, YQ Deng, P Zou, Q Wang, Y Dai, F Yu… - Nature …, 2017 - nature.com
Zika virus (ZIKV), a re-emerging flavivirus associated with neurological disorders, has
spread rapidly to more than 70 countries and territories. However, no specific vaccines or
antiviral drugs are currently available to prevent or treat ZIKV infection. Here we report that a …


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*Peptide Synthesis: From short peptides to long peptides, linear peptides to cyclic peptides.
*Peptide Modifications: Peptide-protein conjugation, D-amino acid peptides, isotope peptides, fluorescent peptides, multiple antigen peptides, multiple disulfide bridge peptides, phosphopeptides etc.
*Catalog Peptides: ACE Inhibitors, Amyloids & Related Peptides, Antimicrobial Peptides, Apelin Peptides, Myelin Oligodendrocyte Glycoprotein (MOG) Peptides, TAT Proteins etc.
*Peptide Salt: TFA, Desalt, Acetate, HCl.
*Peptide Purity: From crude to ＞99.5%.
*Production Capacity: From mg to kg, with a capacity of synthesizing 15,000 peptides/month.
*Peptide Library Synthesis: Alanine Scan, Overlapping, Positional Scan, T-cell Truncated, Scrambled ect.

Eva He
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Pepmic Co., Ltd
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