2018年10月29日星期一

One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer

One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer

KM Luginbuhl, JL Schaal, B Umstead… - Nature biomedical …, 2017 - nature.com
Stimulation of the glucagon-like peptide-1 (GLP1) receptor is a useful treatment strategy for
type 2 diabetes due to pleiotropic effects, such as the regulation of islet hormones and the
induction of satiety. However, the native ligand for the GLP1 receptor has a short half-life …


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