2018年10月23日星期二

[HTML] Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density

[HTML] Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density

CH Yeh, T Nojima, M Kuraoka, G Kelsoe - Nature communications, 2018 - nature.com
B cells expressing high affinity antigen receptors are advantaged in germinal centers (GC),
perhaps by increased acquisition of antigen for presentation to follicular helper T cells and
improved T-cell help. In this model for affinity-dependent selection, the density of …


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