2018年10月29日星期一

Peptide blockers of Kv1. 3 channels in T cells as therapeutics for autoimmune disease

Peptide blockers of Kv1. 3 channels in T cells as therapeutics for autoimmune disease

KG ChandyRS Norton - Current opinion in chemical biology, 2017 - Elsevier
The voltage-gated K v 1.3 channel in T lymphocytes is a validated therapeutic target for
diverse autoimmune diseases. Here we review the discovery of K v 1.3, its physiological role
in T cells, and why it is an attractive target for modulating autoimmune responses. We focus …


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