[HTML] Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

[HTML] Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death

S Thellung, B Scoti, A Corsaro, V Villa, M Nizzari… - Cell death & …, 2018 - nature.com

According to the “gain-of-toxicity mechanism”, neuronal loss during cerebral proteinopathies
is caused by accumulation of aggregation-prone conformers of misfolded cellular proteins,
although it is still debated which aggregation state actually corresponds to the neurotoxic …

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