Positive Charge in the n-region of the Signal Peptide Contributes to Efficient Post-translational Translocation of Small Secretory Proteins

Positive Charge in the n-region of the Signal Peptide Contributes to Efficient Post-translational Translocation of Small Secretory Proteins

M Liu, J Sun, Y Xiong, J Cui, H Guo - The FASEB Journal, 2017 - fasebj.org

A majority of secretory proteins in mammalian cells undergo signal recognition particle
(SRP) dependent co-translationally translocation across the endoplasmic reticulum (ER).
However, due to minimal time for SRP recognition, many small secretory proteins can be …

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