Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

IR Chassagnon, CA McCarthy… - Proceedings of the …, 2017 - National Acad Sciences

Stroke is the second-leading cause of death worldwide, yet there are no drugs available to
protect the brain from stroke-induced neuronal injury. Acid-sensing ion channel 1a (ASIC1a)
is the primary acid sensor in mammalian brain and a key mediator of acidosis-induced …

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