2019年2月14日星期四

Monoclonal antibodies against metzincin targets

Monoclonal antibodies against metzincin targets

S Santamaria, R de Groot - British journal of pharmacology, 2019 - Wiley Online Library
… Metzincins are metallopeptidases that share a highly sim- ilar catalytic site. This contains
three histidines that coordi- nate a zinc ion and a glutamate, which together with a bound
water molecule drive the hydrolysis of the substrate peptide bond …


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