Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors

Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors

Z Wang, W Watt, NA Brooks, MS Harris, J Urban… - … et Biophysica Acta (BBA …, 2010 - Elsevier

... [49]). Purified caspase-3 and purified and refolded caspase-8 were about 90% and
85% active, respectively by active site titration. Caspase substrates, Ac-DEVD-AMC
and Ac-IETD-AMC, were purchased from Peptide Institute, Inc. ...

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