2018年8月11日星期六

Rational modification of a dendrimeric peptide with antimicrobial activity: consequences on membrane-binding and biological properties

Rational modification of a dendrimeric peptide with antimicrobial activity: consequences on membrane-binding and biological properties

G Batoni, M Casu, A Giuliani, V Luca, G Maisetta… - Amino acids, 2016 - Springer
Peptide-based antibiotics might help containing the rising tide of antimicrobial resistance.
We developed SB056, a semi-synthetic peptide with a dimeric dendrimer scaffold, active
against both Gram-negative and Gram-positive bacteria. Being the mechanism of SB056 …


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