A peptide derived from a β2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation

A peptide derived from a β2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation

TE Hebert, S Moffett, JP Morello, TP Loisel… - Journal of Biological …, 1996 - ASBMB

One of the assumptions of the mobile receptor hypothesis as it relates to G protein-coupled
receptors is that the stoichiometry of receptor, G protein, and effector is 1: 1: 1 (Bourne, HR,
Sanders, DA, and McCormick, F.(1990) Nature 348, 125–132). Many studies on the …

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