Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms

Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms

MA Fischbach, CT Walsh - Chemical reviews, 2006 - ACS Publications

Many thousands of small molecule natural products with interesting biological activities are
polyketides (PK), nonribosomal peptides (NRP), or hybrids thereof (ie, PK-NRP hybrids).
Examples include the polyketide antibiotics erythromycin1 and tetracycline, 2 the …

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