2018年10月22日星期一

IKK alpha Antibody

Product  IKK alpha Antibody
Cat#  100-21-53A
Unit/Weight  100 μg
Unit Price  $311.00
Species Reactivity  H
Tested Application(s)  E, WB, ICC
Brief Description  (C3) Ikappa B kinase alpha
Specific Description  Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappaB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and bacteria product LPS. NF-kappaB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kappaB activity. The long-sought IΚB kinase (IKK), which phosphorylates IkappaB, and mediates IkappaB degradation and NF-kappaB activation, was recently identified by several laboratories (1-5). IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKalpha and IKKΒ). IKKalpha and IKKbeta interact with each other and both are essential for the NF-kappaB activation. IKKalpha specifically phosphorylates IkappaB-alpha. IKKalpha is expressed in a variety of human tissues.
Storage  IKK alpha antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

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