Structural basis for selective therapeutic targeting of BFL-1 in cancer by a covalent stapled peptide inhibitor

Structural basis for selective therapeutic targeting of BFL-1 in cancer by a covalent stapled peptide inhibitor

EP Harvey, HS Seo, RM Guerra, GH Bird… - 2018 - AACR

BCL-2 family proteins are master regulators of the mitochondrial apoptotic pathway and
dictate whether a cell will live or die in response to stress. Cancer cells hijack the anti-
apoptotic arm of this signaling network, overexpressing BCL-2, MCL-1, and BFL-1, to …

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