2018年10月11日星期四

TIM-4 Antibody

Product  TIM-4 Antibody
Cat#  100-12-52A
Unit/Weight  100 μg
Unit Price  $311.00
Species Reactivity  H, M
Tested Application(s)  E, WB, ICC
Brief Description  (IN) T cell immunoglobulin and mucin domain containing protein 4
Specific Description  The T cell immunoglobulin and mucin domain containing protein (TIM) family encodes cell surface receptors that are involved in the regulation of T helper (Th) -1 and -2 cell-mediated immunity. TIM-4, which is preferentially expressed on macrophages and dendritic cells, is the natural ligand of TIM-1, and this binding leads to T-cell expansion and cytokine production. Unlike other members of the TIM family, TIM-4 lacks a putative tyrosine phosphorylation signal sequence in its intracellular domain. The TIM-4 gene maps to a locus associated with predisposition to asthma in both mice and humans and with its connection to TIM-1-triggered Th2 responsiveness, may be considered as a candidate disease/predisposition gene for asthma.
Storage  TIM-4 antibody can be stored at 4°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

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