β-Lactone formation during product release from a nonribosomal peptide synthetase

β-Lactone formation during product release from a nonribosomal peptide synthetase

JE Schaffer, MR Reck, NK Prasad… - Nature chemical …, 2017 - nature.com

Nonribosomal peptide synthetases (NRPSs) are multidomain modular biosynthetic
assembly lines that polymerize amino acids into a myriad of biologically active nonribosomal
peptides (NRPs). NRPS thioesterase (TE) domains employ diverse release strategies for off …

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