[HTML] BDNF pro-peptide regulates dendritic spines via caspase-3

[HTML] BDNF pro-peptide regulates dendritic spines via caspase-3

J Guo, Y Ji, Y Ding, W Jiang, Y Sun, B Lu… - Cell death & …, 2016 - nature.com

The precursor of brain-derived neurotrophic factor (BDNF)(proBDNF) is enzymatically
cleaved, by either intracellular (furin/PC1) or extracellular proteases (tPA/plasmin/MMP), to
generate mature BDNF (mBDNF) and its pro-peptide (BDNF pro-peptide). Little is known …

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