Residues in the hydrophobic signal peptide region and charges at the amino-terminus of the mature human CD4 protein region contribute to CADA sensitivity

Residues in the hydrophobic signal peptide region and charges at the amino-terminus of the mature human CD4 protein region contribute to CADA sensitivity

V Van Puyenbroeck, A Giraut, TW Bell, D Schols… - 2016 - lirias.kuleuven.be

The small molecule macrocycle cyclotriazadisulfonamide (CADA) was identified as a signal
peptide-binding inhibitor of co-translational translocation, which prevents the translocation of
human CD4 across the ER membrane. Initial experiments with human/mouse CD4 hybrids …

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