Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide.

Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide.

A Hatami, S Monjazeb, S Milton, CG Glabe - Journal of Biological Chemistry, 2017 - ASBMB

Most cases of Alzheimer's disease (AD) are sporadic, while a small percentage of AD cases,
called familial AD (FAD), are associated with mutations in presinilins 1 and 2 and the
amyloid precursor protein (APP). APP mutations falling within the Aβ sequence lead to a …

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