β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial
I Raz, D Elias, A Avron, M Tamir, M Metzger, IR Cohen - The Lancet, 2001 - Elsevier
BACKGROUND: Type 1 diabetes results from autoimmune destruction of insulin-producing
pancreatic β cells. The 60 kDa heat-shock protein (hsp60) is one of the known target self
antigens. An immunomodulatory peptide from hsp60, p277, arrested β-cell destruction and
pancreatic β cells. The 60 kDa heat-shock protein (hsp60) is one of the known target self
antigens. An immunomodulatory peptide from hsp60, p277, arrested β-cell destruction and
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