Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors
J Kwon, SR Lee, KS Yang, Y Ahn… - Proceedings of the …, 2004 - National Acad Sciences
Abstract Stimulation of cells with various peptide growth factors induces the production of
phosphatidylinositol 3, 4, 5-trisphosphate (PIP 3) through activation of phosphatidylinositol 3-
kinase. The action of this enzyme is reversed by that of the tumor suppressor PTEN. With the
phosphatidylinositol 3, 4, 5-trisphosphate (PIP 3) through activation of phosphatidylinositol 3-
kinase. The action of this enzyme is reversed by that of the tumor suppressor PTEN. With the
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