2018年1月29日星期一

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

Selectivity of MHC-encoded peptide transporters from human, mouse and rat

F Momburg, J Roelse, JC Howard, GW Butcher… - Nature, 1994 - nature.com
Abstract MAJOR histocompatibility complex (MHC) class I molecules present peptides from
degraded intracellular antigens to CD8+ T cells 1. These peptides are translocated in an
ATP-dependent fashion 2–4 into the lumen of the endoplasmic reticulum (ER) for binding to


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