Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B
PTP1B specifically dephosphorylates pTyr-containing proteins (11). Free pTyr is a relatively poor
substrate [Michaelis constant (K sub m ), 5 mM] compared with pTyr peptides, suggesting that
the primary determinant. of specificity is a pTyr residue in the context of a peptide and that flanking
substrate [Michaelis constant (K sub m ), 5 mM] compared with pTyr peptides, suggesting that
the primary determinant. of specificity is a pTyr residue in the context of a peptide and that flanking
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