2018年9月2日星期日

Acetone‐linked peptides: a convergent approach for peptide macrocyclization and labeling

Acetone‐linked peptides: a convergent approach for peptide macrocyclization and labeling

N Assem, DJ Ferreira, DW Wolan… - Angewandte Chemie …, 2015 - Wiley Online Library
Macrocyclization is a broadly applied approach for overcoming the intrinsically disordered
nature of linear peptides. Herein, it is shown that dichloroacetone (DCA) enhances helical
secondary structures when introduced between peptide nucleophiles, such as thiols, to yield …


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