2018年9月1日星期六

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

MS Trabelsi, M Daoudi, J Prawitt, S Ducastel… - Nature …, 2015 - nature.com
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and
the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen
and decrease intestinal FXR activity. The BAS–BA complex also induces glucagon-like …


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