Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 Å
O Livnah, EA Stura, DL Johnson, SA Middleton… - …, 1996 - science.sciencemag.org
The functional mimicry of a protein by an unrelated small molecule has been a formidable
challenge. Now, however, the biological activity of a 166-residue hematopoietic growth
hormone, erythropoietin (EPO), with its class 1 cytokine receptor has been mimicked by a 20 …
challenge. Now, however, the biological activity of a 166-residue hematopoietic growth
hormone, erythropoietin (EPO), with its class 1 cytokine receptor has been mimicked by a 20 …
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