[HTML] Clearance of Alzheimer's amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

[HTML] Clearance of Alzheimer's amyloid-β_1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

M Shibata, S Yamada, SR Kumar… - The Journal of …, 2000 - Am Soc Clin Investig

Deposition of amyloid-β peptide (Aβ) in the brain occurs during normal aging and is
accelerated in patients with Alzheimer's disease (AD). Aβ is central to the pathology of AD,
and is the main constituent of brain parenchymal and vascular amyloid (1–6). Aβ extracted …

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