Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.
AC Karaplis, A Luz, J Glowacki… - Genes & …, 1994 - genesdev.cshlp.org
The parathyroid hormone-related peptide (PTHrP) gene was disrupted in murine embryonic
stem cells by homologous recombination, and the null allele was introduced into the mouse
germ line. Mice homozygous for the PTHrP null mutation died postnatally, probably from …
stem cells by homologous recombination, and the null allele was introduced into the mouse
germ line. Mice homozygous for the PTHrP null mutation died postnatally, probably from …
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