Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide
P Seubert, T Oltersdorf, MG Lee, R Barbour… - Nature, 1993 - nature.com
THE accumulation in brain of senile plaques containing β-amyloid protein (Aβ) is a defining
feature of Alzheimer's disease 1–3. The amyloid precursor protein (APP) 4 from which Aβ is
derived is subject to several genetic mutations which segregate with rare familial forms of …
feature of Alzheimer's disease 1–3. The amyloid precursor protein (APP) 4 from which Aβ is
derived is subject to several genetic mutations which segregate with rare familial forms of …
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