A Cyclic Peptide Inhibitor of the iNOS–SPSB Protein–Protein Interaction as a Potential Anti-Infective Agent

A Cyclic Peptide Inhibitor of the iNOS–SPSB Protein–Protein Interaction as a Potential Anti-Infective Agent

MM Sadek, N Barlow, EWW Leung… - ACS chemical …, 2018 - ACS Publications

SPRY domain-and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4 interact with
inducible nitric oxide synthase (iNOS), causing the iNOS to be polyubiquitinated and
targeted for degradation. Inhibition of this interaction increases iNOS levels, and …

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