A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics
CG Santiago, E Paci, D Donnelly - Biochemical and biophysical research …, 2018 - Elsevier
The receptor for glucagon-like peptide 1 (GLP-1R) is a validated drug target for the treatment
of type 2 diabetes and obesity. Recently the first three structures of GLP-1R were published–
an X-ray structure of the apo transmembrane domain in the inactive conformation; an X-ray …
of type 2 diabetes and obesity. Recently the first three structures of GLP-1R were published–
an X-ray structure of the apo transmembrane domain in the inactive conformation; an X-ray …
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