2018年11月25日星期日

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

R ZhangJJ Miner, MJ Gorman, K Rausch, H Ramage… - Nature, 2016 - nature.com
Flaviviruses infect hundreds of millions of people annually, and no antiviral therapy is
available 1, 2. We performed a genome-wide CRISPR/Cas9-based screen to identify host
genes that, when edited, resulted in reduced flavivirus infection. Here, we validated nine …


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