2018年11月25日星期日

[HTML] Familial Alzheimer's disease mutations in presenilin generate amyloidogenic Aβ peptide seeds

[HTML] Familial Alzheimer's disease mutations in presenilin generate amyloidogenic Aβ peptide seeds

S Veugelen, T SaitoTC Saido, L Chávez-Gutiérrez… - Neuron, 2016 - Elsevier
Recently it was proposed that the familial Alzheimer's disease (FAD) causing presenilin
(PSEN) mutations PSEN1-L435F and PSEN1-C410Y do not support the generation of Aβ-
peptides from the amyloid precursor protein (APP). This challenges the amyloid hypothesis …


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